Tomáš Pluskal Group at IOCB Prague combines cutting-edge experimental (e.g., LC-MS, metabolomics, RNA-seq) and computational (e.g., bioinformatics, molecular networking, machine learning) approaches to develop rapid, generally applicable workflows for the discovery and utilization of bioactive molecules derived from plants.

The lab is looking for a talented and motivated postdoctoral fellow with experience in metabolic engineering to join the team.

The successful candidate will be developing a new yeast-based platform with targeted genetic modifications to induce accumulation of metabolic building blocks and precursors. This platform will be subsequently used for the biosynthesis of valuable medicinal compounds.

The IOCB is one of the leading research institutes in central Europe with a vibrant international environment and excellent equipment and core facilities located in modern buildings close to the Prague city center.


  • PhD degree in the field of metabolic engineering, metabolomics, or molecular biology obtained no more than 5 years ago
  • Hands-on experience with high-resolution LC-MS analysis and metabolomics data processing
  • Good track record of previous scientific publications and achievements
  • Good proficiency in spoken and written English
  • Passion for basic research and science

We offer

  • Competitive salary
  • 5 weeks of vacation
  • Health insurance and full benefits package incl. contribution to pension, culture, and sport
  • Lunch subsidy
  • Other IOCB employee benefits

How to apply

Please email your CV with a list of publications, a cover letter or a research statement, and contact details of 2-3 references to Dr. Tomáš Pluskal: tomas.pluskal@uochb.cas.cz.


The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences / IOCB Prague is a leading internationally recognized scientific institution whose primary mission is the pursuit of basic research in chemical biology and medicinal chemistry, organic and materials chemistry, chemistry of natural substances, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. An integral part of the IOCB Prague’s mission is the implementation of the results of basic research in practice. Emphasis on interdisciplinary research gives rise to a wide range of applications in medicine, pharmacy, and other fields.