Job Description

A postdoctoral position in Targeted Research Group HBV Cure (head Gabriel Birkuš, Ph.D.) at the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) is available for a highly motivated and creative scientist with expertise in organic chemistry. The project is focused on the identification of novel cGAS inhibitors.

GMP-AMP synthase (cGAS) serves as a sensor of cytosolic dsDNA and plays an essential role in innate immunity against viral/bacterial infection and cellular damage. Upon binding of dsDNA, cGAS synthesizes a cyclic dinucleotide 2’3’cGAMP that serves as a second messenger and initiates an inflammatory cellular response. Uncontrolled activation of the cGAS pathway has been implicated in autoimmune and autoinflammatory diseases such as Aicardi-Goutieres syndrome or Systemic Lupus Erythematosus. Thus, inhibition of cGAS may be of therapeutic benefit in some diseases.

The successful candidate will be a member of a multidisciplinary team and involved in our efforts to identify novel cGAS inhibitors. He or she will be responsible for the synthesis of target compounds. The candidate will also have a unique opportunity to experience the lead optimization process of drug development. An attractive salary and an opportunity to work with clinical candidates are guaranteed.


The applicant must have a Ph.D. in organic chemistry. We are looking for applicants with excellent expertise in synthetic organic chemistry, and with knowledge of analytical and spectroscopic methods. Experience in medicinal chemistry is an advantage. Good oral and written communication skills in English are required. The position is available starting from now.

We offer

  • Competitive salary
  • 5 weeks of vacation
  • Health insurance and full benefits package incl. contribution to pension, culture, and sport
  • Lunch subsidy
  • Other IOCB employee benefits


Please submit your resume, motivation letter, and contact information by e-mail to Ondřej Páv, Ph.D.: ondrej.pav@uochb.cas.cz.

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences / IOCB Prague (www.uochb.cz) is a leading internationally recognized scientific institution whose primary mission is the pursuit of basic research in chemical biology and medicinal chemistry, organic and materials chemistry, chemistry of natural substances, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. An integral part of the IOCB Prague’s mission is the implementation of the results of basic research in practice. Emphasis on interdisciplinary research gives rise to a wide range of applications in medicine, pharmacy, and other fields.