The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is seeking a motivated and service-minded facility manager for its new cryo-EM facility, which will house a 300 keV high-resolution and a 200 keV screening microscope with microED capability. The facility will be located in a new extension of the main building on the historic IOCB campus. The primary responsibility as head of the facility will be to ensure the smooth, hassle-free operation of the microscopes to enable the collection of high-quality data sets. Other duties will include providing guidance and training in sample preparation, data acquisition, and image processing for internal users. In addition, beginning with the installation process and commissioning of the microscopes, the facility manager is expected to support and work closely with architects and engineers during the design and setup phases of the facility. Therefore, a thorough understanding of the technical requirements of the installation is required.

IOCB Prague in a nutshell

  • A leading research institute in the Czech Republic and Central Europe, under the auspices of the Czech Academy of Sciences
  • Operates at the interface of biology, organic and physical chemistry, offering a unique cross-disciplinary environment, while maintaining above-critical mass in each discipline
  • International environment with English as a working language
  • Equal opportunity employer
  • Financially stable environment, enabling core funding and sustainable development
  • Cutting-edge technology and equipment
  • The completely renovated campus located in a desirable area of Prague close to the international Vaclav Havel Airport and the city center, superbly connected by public transport
  • Powerful system of technology transfer aimed at successful commercialization of relevant results
  • Collaboration with top research institutes and commercial partners worldwide

The position offers:

  • Establishment of a new cryo-EM facility and associated group at IOCB
  • Full-time contract (reconfirmed as permanent position after 1 year)
  • Competitive salary and benefits
  • A start-up package including investments in all necessary equipment for the cryo-EM facility and consumables; core funding for the salary of up to 3 co-workers
  • Access to outstanding research infrastructure of IOCB
  • Assistance and financial support to parents with small children
  • Relocation support and help

The successful candidate:

We are looking for a candidate who is approachable, friendly, and has a service-minded, innovative, and communicative personality. The facility manager’s task will be to guide users, discuss their problems, and help them achieve their goals by providing his/her expertise to the best of his/her abilities.

The successful candidate will have a profound knowledge of operating and managing high-end cryo-EM instrumentation and data-acquisition software for single-particle data collection and structure determination. She/he will also have hands-on experience in the handling and preparation of a wide variety of protein samples for subsequent imaging using state-of-the-art plunge-freezing equipment. Prior core facility experience, familiarity with microED data collection, and experience in protein isolation and purification are advantages.


Applicants should submit their curriculum vitae, a 1-2-page description of their experience and accomplishments in the field of single-particle cryo-EM, including a description of their two most relevant publications, and a motivation letter in which they describe their vision for user training and interaction with IOCB research groups and why they would like to head a service facility.

Furthermore, applicants should also arrange for three letters of reference to be sent directly to the IOCB director Dr. Zdeněk Hostomský at zdenek.hostomsky@uochb.cas.cz, who can also provide further information.


Applications must be submitted electronically in English no later than 15 September 2020 as a single PDF document to uochb@uochb.cas.cz with the subject “Cryo-EM application”. Interviews will be conducted in October 2020. The expected start is January 2021 or later based on an agreement with the selected candidate.