Understanding TBEV replication. Tick Borne Encephalitis Virus is a single-stranded RNA virus, which replicates in association with the host Endoplasmatic Reticulum (ER) forming dynamic and well-orchestrated Replication Complex (RC). Despite its importance, the molecular composition and structure of the RC, as well as the interaction among individual constituents and precise mechanism of RNA replication is still largely unknown. We combine various molecular-biological, biochemical, biophysical and structural techniques to explore the formation and function of RC within membrane bilayer.

Contact: Zdeněk Franta, zfranta@prf.jcu.cz, Supervisors: Zdeněk Franta, Filip Dyčka (fdycka@prf.jcu.cz), Zdeno Gardian (gardian@prf.jcu.cz), Tomáš Fessl (fessl@prf.jcu.cz), Roman Tůma (rtuma@prf.jcu.cz)

More about PhD study at Institute of Physics: https://www.prf.jcu.cz/en/ufy/studies/biophysics.html