Přehled

Tutor Prof. Pavel Jungwirth, Ph.D.
Team Pavel Jungwirth
Topic Simulations of translocation processes in cellular membranes
Faculty FCHI VŠCHT, MFF UK
Abstract The dissertation will focus on molecular simulations aiming to unravel at the molecular level key processes connected with translocation across cell membranes. Particular attention is paid to effects due to oxidative stress, ions, and specific membrane-associated peptides and proteins that are involved in numerous human diseases.

References:
1. Timr S., Pleskot R., Kadlec J., Kohagen M., Magarkar A., Jungwirth P.: Membrane Binding of Recoverin: From Mechanistic Understanding to Biological Functionality. ACS Central Science 3 (2017) 868.
2. Melcrová A., Pokorná S., Pullanchery S., Kohagen M., Jurkiewicz P., Hof M., Jungwirth P., Cremer P.S.: The Complex Nature of Calcium Cation Interactions with Phospholipid Bilayers. Scientific Reports 6 (2016) 38035.
3. Robison A.D., Sun S., Poyton M.F., Johnson G.A., Pellois J.-P., Jungwirth P., Vazdar M., Cremer P.S.: Polyarginine Interacts More Strongly and Cooperatively than Polylysine With Phospholipid Bilayers. Journal of Physical Chemistry B 120 (2016) 9287.
4. Allolio C., Baxova K., Vazdar M., Jungwirth P.: Guanidinium Pairing Facilitates Membrane Translocation. Journal of Physical Chemistry B 120 (2016) 143.

More information & How to apply
Find more projects and see how to apply at www.iocb.cz/phd. (Please note: Deadline for applications is February 21, 2019; IOCB Interview Day is on March 14, 2019)