Přehled
The topic of the dissertation will be the design and enzymatic synthesis of hypermodified xeno-nucleic acids with a combination of modifications at the base, sugar moiety and phosphate linkages. After optimization of the methodology, hypermodified XNA oligonucleotides will be prepared and tested as potential therapeutics.
University: Faculty of Chemical Technology, UCT Prague; Faculty of Science, Charles University
Group: Michal Hocek Group / Bioorganic and Medicinal Chemistry of Nucleic Acids
Tutor: Prof. Ing. Michal Hocek, Ph.D. DSc.
Field of study: Organic chemistry
