At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We are offering more than 20 new exciting projects in organic and medicinal chemistry, biochemistry, molecular biology, analytical, and physical chemistry.

  • Online registration deadline: 20 February 2023
  • Interview Day: 23 March 2023

Learn more and apply at https://www.uochb.cz/en/call-for-phd-applications

Viral proteases are indispensable for successful viral replication as well as important pathogenic factors. Better understanding of their action is important for future therapies.

The work will focus mainly to proteases from flaviviruses (Zika, Dengue), coronaviruses (SARS-CoV-2) and retroviruses (HIV).

The experimental work will include cloning, protein expressions, purifications, biophysical characterizations and crystallizations, handling with small-compounds libraries and biological libraries, tissue culture work and analyses (microscopy, flow cytometry), development and adaptation of enzymological and cell based phenotypic assays.

The outputs will help to better understand pathogenesis and possibilities of targeting of viral proteases.

University: Faculty of Science, Charles University
Field of study: Physical chemistry
Tutor: Dr. Taťána Majerová
Group: Jan Konvalinka Group – Proteases of Human Pathogens