At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We are offering more than 20 new exciting projects in organic and medicinal chemistry, biochemistry, molecular biology, analytical, and physical chemistry.

  • Online registration deadline: 20 February 2023
  • Interview Day: 23 March 2023

Learn more and apply at https://www.uochb.cz/en/call-for-phd-applications

The project is focused on proteolytic enzymes of the cathepsin type that are critically involved in pathologies and are therapeutic targets. Cathepsins of human origin and those from pathogens and parasites will be investigated. The aim of the project is to analyze the structure and function of cathepsins and develop novel inhibitory molecules for their regulation. The research in the field of biochemistry and molecular biology employs the following main approaches: functional proteomics and chemical genomics, recombinant protein expression, enzymology, protein crystallography, and molecular modeling.

University: Faculty of Food and Biochemical Technology, UCT Prague / First Faculty of Medicine, Charles University
Field of study: Biochemistry
Tutor: RNDr. Michael Mareš, CSc.
Group: Michael Mareš Group – Cathepsin Proteases in Pathology