At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We are offering more than 20 new exciting projects in organic and medicinal chemistry, biochemistry, molecular biology, analytical, and physical chemistry.
- Online registration deadline: 20 February 2023
- Interview Day: 23 March 2023
Learn more and apply at https://www.uochb.cz/en/call-for-phd-applications
Viral methyltransferases (MTases) play an essential role in the capping of the newly synthesized viral RNA during the replication process. In flaviviruses, the cap usually consists of 7-N-methylated guanosine 5’- triphosphate and 2’-O-methyladenosine and the MTases are responsible for methylation of both guanosine nucleobase and adenosine sugar moiety. The project will be focused on the synthesis of novel inhibitors targeting these enzymes, which are highly conserved among numerous flaviviruses that are responsible for important human diseases such as tick-borne encephalitis, Dengue, West Nile and Yellow fevers.
University: Faculty of Food and Biochemical Technology, UCT Prague / Faculty of Science, Charles University
Field of study: Organic chemistry
Tutor: Mgr. Radim Nencka, PhD.
Group: Radim Nencka Group – Drug Design and Medicinal Chemistry