We invite applications for a Ph.D. position in the research group Fluorescent Probes under the supervision of Dr. Peter Šebej https://www.recetox.muni.cz/vyzkum/lide/dr-peter-sebej
Polymethine dyes and their conjugates for labelling in biomedical applications
Modern diagnostic methods are often based on molecular biology and immunochemistry approaches allowing to tag and visualize tissues, cells, and cellular structures based on various types of electromagnetic radiation. Conjugates of fluorescent molecules and nanoparticles are among the most often used visualization modalities. We aim to combine molecular design, organic synthesis, bioconjugation and cell labelling with tags emitting primarily in tissue transparent window to overcome limitations of traditional fluorescent tags.
The candidate will perform synthesis and characterization of organic small molecular fluorophores alone and in larger covalent constructs and will study their properties. Assessment of structure-properties relationship will allow to rationally design such dyes and apply them in vitro and in vivo in models of various complexity. Highly motivated and skilful candidates will have the opportunity to considerably extend their graduate training in chemistry by learning advanced spectroscopic methods, photochemistry, bioconjugations, and will also take part in close collaboration with biologists.
RECETOX Ph.D. student position
- 4-year Ph.D. programme with financial support for 4 years
- Interdisciplinary scientific topics
- Supervision by experienced mentors and excellent scientists and tailored study plan
- Excellent and state-of-the-art research infrastructure
- International mobility and internships
- International and friendly environment
- Courses developing transferable skills
The candidate shall possess MSc. or a corresponding degree in chemistry or area related to the field, a solid background in the respective field, and good communication skills in the English language, both oral and written.
Discussion about the research topic with the supervisor is mandatory before the formal application – contact directly Peter Šebej at firstname.lastname@example.org
For a consultation with the supervisor, candidates should submit the application, including (i) curriculum vitae; (ii) motivation letter; (iii) contacts of three persons who might provide references; and (iv) ideally a sample of written work (e.g., MSc. thesis or previous publications).
Application, which are not submitted in English, Czech or Slovak language will not be included in the selection process.
The deadline for applications is on 20 April 2021. A review of applications will run continuously as they are received and until the position is filled. The short-listed applicants complying with the requirements will be invited for personal or Skype interviews.
Formal application to Ph.D. studies at Masaryk University will then require further documentation and formalities from the candidates and will be processed through an electronic application system.
Masaryk University is the second-largest university in the Czech Republic with nine faculties, more than 5000 staff, and more than 30 000 students. As a comprehensive research-intensive university with a strong international standing, our mission is to pursue top-quality research and education.
Faculty of Science MU, a proud holder of the HR Excellence in Research Award by the European Commission, is a research-oriented faculty, offering university education (Bachelor’s, Master’s, and Doctoral degree programs) closely linked to both primary and applied research and high school teaching of the following sciences: Mathematics, Physics, Chemistry, Biology, and Earth sciences. We are the most productive scientific unit of Masaryk University, generating around 40 % of MU research results.
Brno, the capital city of the South Moravian Region, situated approximately halfway between Prague and Vienna, it is the largest university town in the Czech Republic and a modern metropolis with a long history and culture. Recognizing the university’s significant role in making Brno one of the most innovative cities in the CEE region, it continuously supports, together with the South Moravian Region, the local scientific, start-up, and high-tech communities.