Bioorganic and Medicinal Chemistry of Nucleic Acids
New types of modified mRNA bearing diverse substituents at nucleobases will be prepared by polymerase incorporation of modified nucleoside triphosphates and the influence of these non-natural substituents on interactions with proteins as well as on translation will be studied.
Field of study: Organic chemistry
- Milisavljevič, N.; Perlíková, P.; Pohl, R.; Hocek, M.: „Enzymatic synthesis of base-modified RNA by T7 RNA polymerase. A systematic study and comparison of 5-substituted pyrimidine and 7-substituted 7-deazapurine nucleoside triphosphates as substrates“ Org. Biomol. Chem. 2018, 16, 5800-5807.
PhD students must be enrolled in a partner university and will be employed by the IOCB Prague at the same time (part-time or full time), which results in a competitive salary (a scholarship from the university + a salary from the IOCB). Each university has its own process, terms, and deadlines for PhD applications, which is separate from the IOCB recruitment process. You may discuss the details with the respective PI.
Faculty of Science, Charles University
Faculty of Chemical Technology, University of Chemistry and Technology, Prague
Faculty of Food and Biochemical Technology, University of Chemistry and Technology, Prague