Assigned Work:

Research project activities at the Department of Pharmacology, CardioTox In Vivo Research Group, in experimental cardio-oncology with focus on the oncological part of the topic. The work will mainly involve employment in vivo animal models (tumour xenograft bearing mice) to study effects of anticancer drugs on the tumour and the heart. Molecular insights to the studied effects will be obtained using standard techniques (mainly qRT-PCR and Western blot) with special interest in the role of topoisomerase II, DNA damage, DNA-damage response and chromatin damage.

Application requirements:

  • Ph.D. or equivalent academic degree (equivalent to ISCED level 8) in a biomedical program (Oncology/Cancer Research, Pharmacology or related field). PhD candidates currently finishing their degrees can also apply, but formal confirmation of their successful PhD defence will be a mandatory requirement for entering this position.
  • Be a Junior researcher according to definition of OP JAC, which means a researcher who was awarded his/her Ph.D. no more than 7 years ago (exceptions apply);
  • Demonstrated publication activity and experimental experience in the relevant research field, grant activity is an advantage;
  • Prerequisite skills for research and scientific work;
  • Experience with in vivo tumour xenograft experiments as an advantage;
  • Experience with topoisomerase II, DNA damage, DNA-damage response, chromatin damage, cancer cells or cardio-oncology experiments as an advantage.
  • Experience with qRT-PCR and/or Western Blotting as an advantage;
  • Active knowledge of English; Czech language as an advantage;
  • PC skills;
  • Teamwork skills;
  • Health capacity for work, moral integrity.

Please, provide the following documents:

  • Cover letter;
  • Structured CV including an overview of scientific activities, past research experience and publication outputs;
  • letter(s) of recommendation from recognized experts in their research field
  • Scanned copy of the diploma (Ph.D. degree) or the confirmation of Ph.D. studies;
  • In the body of the e-mail message: “Consent for the use of personal information for the purpose of this Call” in accordance with Act No. 101/2000, on the Protection of Personal Data and on Amendments to Certain Acts, as amended.

We offer:

  • Work for a prestigious educational and scientific institution of Charles University;
  • Full-time or part-time (min. 28 hours/week);
  • The estimated monthly wage: 55000 CZK/2200 EUR (1,0);
  • 5 weeks of vacation per year + 5 personal development days;
  • Opportunities for professional development and international collaboration;
  • Specialized professional growth and continuous education in a field with a perspective of long-term employment;
  • Participation in international conferences;
  • System of employee benefits (e.g. meal allowance, contribution to supplementary pension insurance or private life insurance, Charles University discounts and benefits at external entities).

Position available from 1st of July 2024 for 28 – 39 months depending on the full-time/part time employment (latest end of contract is 30th of September 2027).

Applications along with all supporting documents should be sent to: podatelna@lfhk.cuni.cz by June 10, 2024, email subject: “OncoPharm – Junior researcher”.

For further questions about the position please contact: Assoc. Prof. Martin Štěrba, PharmD., PhD., Research Gate Profile, Email: sterbam@lfhk.cuni.cz.

prof. MUDr. Jiří Manďák, Ph.D.