|Tutor||Ing. Petr Beier, Ph.D.|
|Topic||Fluoroalkylated hypervalent iodine compounds for bioconjugations|
|Faculty||FCHT UCT, PřF UK|
|Abstract||Fluorinated hypervalent iodine compounds such as Togni reagents have become widely used electrophilic trifluoromethylating reagents.1 They display a unique reactivity profile and functional group compatibility. Recently, in our group we have prepared substituted tetrafluoroethylene-containing reagents and have shown their application in reactions with various nucleophiles.2,3 In this project, we aim to synthetize fluoroalkylated hypervalent iodine reagents bearing a functional group and investigate their utilization in tagging biomolecules such as peptides in electrophilic or radical fashion. New bioconjugation approaches are of great interest to biochemists.
More information & How to apply
Find more projects and see how to apply at www.iocb.cz/phd. (Please note: Deadline for applications is February 21, 2019; IOCB Interview Day is on March 14, 2019)