Tutor Ing. Petr Beier, Ph.D.
Team Petr Beier
Topic Fluoroalkylated hypervalent iodine compounds for bioconjugations
Faculty FCHT UCT, PřF UK
Abstract Fluorinated hypervalent iodine compounds such as Togni reagents have become widely used electrophilic trifluoromethylating reagents.1 They display a unique reactivity profile and functional group compatibility. Recently, in our group we have prepared substituted tetrafluoroethylene-containing reagents and have shown their application in reactions with various nucleophiles.2,3 In this project, we aim to synthetize fluoroalkylated hypervalent iodine reagents bearing a functional group and investigate their utilization in tagging biomolecules such as peptides in electrophilic or radical fashion. New bioconjugation approaches are of great interest to biochemists.

Key references:
1. J. Charpentier, N. Früh, A. Togni Chem. Rev. 2015, 115, 650.
2. V. Matoušek, J. Václavík, P. Hájek, J. Charpentier, Z. E. Blastik, E. Pietrasiak, A. Budinská, A. Togni, P. Beier Chem. Eur. J. 2016, 22, 417.
3. J. Václavík, R. Zschoche, I. Klimánková, V. Matoušek, P. Beier, D. Hilvert, A. Togni Chem. Eur. J. 2017, 23, 6490.

More information & How to apply
Find more projects and see how to apply at www.iocb.cz/phd. (Please note: Deadline for applications is February 21, 2019; IOCB Interview Day is on March 14, 2019)