m Milan Vrábel
Topic Construction of synthetic scaffolds enabling subcellular organelle-specific release chemistry
Abstract Chemical reactions compatible with biological systems offer unique possibility to manipulate and study biological processes under native conditions. Our group has a long term interest in these, so-called, bioorthogonal reactions. They are mainly known as efficient chemical transformations leading to formation of covalent bonds. It has been only recently when the concept was extended to something what is known as bioorthogonal cleavage reactions. The power of this type of reactions is only slowly becoming recognized. In this project, we aim to construct a new type of releasing systems, which will enable de-caging of small molecules within specific cellular compartments. We believe that such systems will offer not only a unique possibility to deliver small biologically active molecules to particular subcellular location, but in a broader sense, to shed light on the function of individual cellular organelles. This project combines organic chemistry with modern chemical biology experiments.

1. Jie Li & Peng R Chen, Development and application of bond cleavage reactions in bioorthogonal chemistry, Nature Chemical Biology 2016, 12, 129-137.

More information & How to apply
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