Přehled

Group:

Pavlína Maloy Řezáčová Group

Tutor:

Ing. Václav Veverka, Ph.D.

Field of study:

Structural Biology

Abstract:

Histone chaperones play an important role in chromatin remodeling. Intrinsically disordered histone chaperones can transition from an unstructured to a structured state upon binding to histones. This type of molecule plays a key role in maintaining chromatin structure and dynamics, DNA replication, transcription and repair. Their deregulation is associated with various diseases, including cancer, underscoring their importance for normal cellular function. The aim of the project will be to study the molecular basis of histone recognition by chaperones, with emphasis on unraveling the role of unstructured regions on the function of these molecules using structural biology techniques (cryo-electron microscopy, NMR spectroscopy or X-ray crystallography).

References:

University:

Faculty of Science, Charles University

How to apply:

At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We are offering more than 20 new exciting projects in organic and medicinal chemistry, biochemistry, molecular biology, analytical, and physical chemistry.

  • Online registration deadline: 3 March 2024
  • Interview Day: 21 March 2024

Learn more and apply at www.uochb.cz/en/call-for-phd-applications.