Our research integrates developmental biology, in vivo disease modeling, and functional drug testing in zebrafish (Danio rerio), together with patient-derived tumor material. We develop and apply xenotransplantation approaches together with complementary model systems to study tumor behavior, signaling mechanisms, and therapeutic vulnerabilities.

The successful candidate will contribute to the development and application of patient-relevant experimental models in a collaborative, multidisciplinary research environment that supports basic and translational biomedical research.

Responsibilities

• Development and application of zebrafish disease and xenotransplantation models
• Tumor cell and tissue transplantation into zebrafish embryos and larvae
• Implementation of patient-derived xenograft and xenotransplantation approaches
• Functional drug response testing using patient-derived material
• High-content and confocal imaging and quantitative phenotype analysis
• Integration of imaging and sequencing datasets
• Participation in collaborative research and supervision of junior researchers

Requirements

• PhD in cancer biology, developmental biology, molecular biology, or a related biomedical field
• Strong interest in in vivo disease modeling and translational cancer research
• Experience with transplantation models, xenografts, or tumor biology is highly desirable
• Experience with zebrafish models is an advantage, but a strong motivation to learn is welcome
• Experience with patient-derived material or translational research is an advantage
• Strong quantitative thinking and data interpretation skills
• Ability to work independently while contributing to collaborative team science
• Excellent communication skills and proficiency in English

We offer

• Highly collaborative, international research environment with strong connections to European research infrastructures and translational research networks
• Access to state-of-the-art imaging, genomics, and high-throughput screening core facilities
• Strong support for scientific and career development within interdisciplinary and translational research programs
• Competitive salary based on experience
• Initial contract for 1 year with the possibility of extension up to 5 years
• 6 weeks of paid vacation
• Access to on-campus sports facilities

How to apply

Candidates should submit a cover letter outlining research interests and suitability for the position, a structured CV, and a list of publications.

Applications should be sent to Ondřej Svoboda (osvoboda@img.cas.cz) and Petr Bartůněk (bartunek@img.cas.cz). Please CC Natalija Romanyuk (natalija.romanyuk@img.cas.cz).

Application deadline: 15 March 2026

For more information, visit www.openscreen.cz and www.img.cas.cz/group/petr-bartunek.