Přehled

Scientist, Molecular Biology and Antibody Discovery 

Plzeň, Czech Republic

Company Summary:

Ampersand Biomedicines is an innovative, privately held biotechnology company leading the way in developing multi-specific medicines that direct a wide range of therapeutic molecules to specific cells and biological contexts (www.Ampersand.bio).  Ampersand was founded in Flagship Pioneering’s venture creation engine, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created.  With a strong emphasis on innovation, Ampersand cultivates a highly dynamic and entrepreneurial environment.

Ampersand Biomedicines’ Pilsen Team, formerly AbCheck and now a Flagship Pioneering Company, discovers and optimizes human therapeutic antibodies with one of the industry’s most versatile technology platforms. Tailored to specific needs and desired Target Product Profiles, the experienced team leverages both cutting-edge (e.g., microfluidics, rabbit mass humanization) and state-of-the-art (e.g., phage display libraries) technologies to provide high quality leads against a range of diverse targets.

Position Summary:

As a Scientist with background in molecular biology, biochemistry or biotechnology you will be responsible for execution of molecular biology processes as well as development and optimization of procedures used in our antibody discovery projects for Ampersand Biomedicines and external customers. Antibody discovery campaigns will include both AbCheck’s proprietary microfluidics pipeline as well as classical phage display approaches. You will work in tight collaboration with teams responsible for immunizations, microfluidic screening and antigen production and be responsible for timely processing of work packages within the antibody discovery platform. The successful candidate will have relevant experience gained at academia or industry, the ability to execute multiple projects in parallel and experience in communication within and beyond the own team.

This role will be based in Plzeň, Czech Republic.

Key Responsibilities: 

• Execute high-throughput amplification and cloning of antibody genes originating from our single-cell discovery platform.
• Clone antigens for cell line generation.
• Generate antibody libraries for a mammalian secretion system.
• Independently design, execute and troubleshoot experiments, analyze data, and routinely present findings during the Molecular Biology and Antibody Engineering and cross-functional team meetings.
• Co-lead modules in antibody discovery campaigns and effectively collaborate with the antibody discovery teams to align on project requirements.
• Manage a team of 1-3 direct reports and provide leadership, guidance, and mentorship to ensure project goals are met effectively and in a timely manner.
• Maintain scientific and technical expertise through familiarity with scientific literature.
• Contribute to building a positive, team-oriented culture.

Qualifications/Experience:

• Ph.D. or equivalent degree in Biochemistry, Biotechnology, Molecular Biology or related field.
• Relevant molecular biology and protein engineering skills for amplification of antibody genes from primary cells and to design and prepare constructs and vectors for mammalian cell line generation.
• Relevant experience with immunoassays (e.g. ELISA).
• Experience with generation of antibody libraries is a plus.
• Experience with protein purification techniques (especially affinity chromatography) and with protein analysis methods is a plus.
• The candidate should possess strong leadership skills, including the ability to mentor 1-3 direct reports, delegate responsibilities, and foster a collaborative work environment.
• Ability to work independently and as part of a team in a fast-paced environment with strong analytical and problem-solving skills, with attention to detail.
• Excellent written and verbal communication skills to effectively present results and scientific data to team leaders, cross-functional teams, academic collaborators, or partners.
• Self-motivated, highly organized, detail-oriented and enthusiastic about playing a pivotal role in a dynamic and multidisciplinary small biotech environment, specifically within the realm of mAb discovery and screening.
• Sense of responsibility regarding experimental work, the team and the mission of Ampersand.
• At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Compensation and grade will be adjusted to the experience level of the applicant.

About Flagship 

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies.

Learn more about Flagship at www.flagshippioneering.com.

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Contact / application: vbulinova@ampersand.bio