Overview

The Institute of Experimental Medicine of the CAS (IEM CAS) is looking for a suitable candidate for the position of Postdoctoral Researcher for the Department of Genome Biology.

Background

We investigate the mechanisms underpinning DNA damage and cancerogenesis, with a focus on:

• Replication Stress & Genome Instability: How oxidative stress in cancer cells leads to the formation of genotoxic R-loops and conflicts between transcription and replication complexes (TRCs).
• The omlecular mechanisms of prevention, signaling, and resolution of replication stress associated with TRCs.
• Exploiting Stress Tolerance: Studying replication stress tolerance pathways to find ways to increase cancer therapy effectiveness.

We offer

• The position is funded by a prestigious 5-year Junior Star Grant from the Czech Science Foundation.
• A full-time, fixed-term employment contract for 2 years, with possible extension.
• Attractive salary, employment benefits, and 5 weeks of vacation per year + 5 sick days.
• A collaborative scientific environment supported by state-of-the-art facilities.
• Opportunities for training and specialised courses to expand a skillset.
• Support to pursue independent funding.

Our requirements

• A PhD in molecular biology, genetics, biochemistry, or a related field.
• Proactive drive, collaborative spirit, a problem-solving mindset.
• Willingness to contribute to the foundational setup of the lab.
• Proficient in both written and spoken English.

Not required but beneficial

• Expertise in the field of DNA repair, replication, or transcription of DNA.
• Experience with advanced technologies, including light microscopy, CRISPR, omics approaches (Chip-seq, proteomics), or bioinformatics.

How to apply

Please send the following to the contact below.

• Cover letter: your motivation to apply for this position and a description of your research interests.
• CV: Highlight your skills, experience, and scientific achievements.
• References: Provide contact details for two referees.
• Application deadline:  February 28th, 2026, or until the position is filled.

The IEM CAS reserves the right to invite only selected candidates for a personal or online interview and the right not to select any of the candidates.

Contact

Hedvika Vlastníková

By replying to this advertisement or by sending your curriculum vitae and any other personal materials to the IEM CAS, you grant consent to the processing and retention of your personal data. This consent remains valid until it is revoked in writing.