A fully-funded postdoctoral position in the Research Group Bioorganic and Medicinal Chemistry of Nucleic Acids (headed by Prof. Michal Hocek) for an initial period of one year (with the possibility to prolong) for a highly motivated and creative scientist with strong expertise in synthetic organic chemistry.

The project will deal with the chemical and enzymatic synthesis of base-modified RNA and XNA for applications in chemical biology and the development of RNA therapeutics.

For more info about our group, research, and publications, see: hocekgroup.uochb.cas.cz.

The successful candidate will work at an excellent European institution with state-of-the-art facilities in an international group of PhD students and postdocs. Prague offers a stimulating atmosphere to accomplish your goals and is an excellent place to live.


  • Ph.D. degree
  • Strong expertise in synthetic organic chemistry, medicinal chemistry, or chemical biology is required
  • Good oral and written communication skills in English
  • Creative practical lab experience
  • Independence, accountability, and reliability
  • Good communication and organizational skills
  • Prior experience with nucleotide and oligonucleotide synthesis and chemistry is an advantage

We offer:

  • Working in a young, promising, and progressive scientific team of biologists, medicinal chemists, virologists, immunologists, computational chemists, and biochemists
  • Competitive financial remuneration
  • 5 weeks of paid vacation plus 4 days of personal leave
  • Health insurance and full benefits package incl. contribution to supplementary pension insurance and contribution to sports/culture leisure time
  • Meal subsidy
  • Financial support for parents with young children
  • State-of-the-art instrumentation portfolio
  • Location in the stunning city of Prague

Additional information:

  • The starting date of the position: immediately or by mutual agreement
  • Initial full-time fixed-term contract for one year, with the possibility of extension

How to apply:

Please send your structured CV, list of publications, and contacts to three persons of reference to Prof. Michal Hocek at michal.hocek@uochb.cas.cz.

Suitable candidates will be contacted to arrange an interview. Please note that if you are not contacted within 5 weeks, we have given preference to candidates who more closely meet the criteria. Thank you for your understanding.

IOCB Prague / Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences is a leading internationally recognized scientific institution whose primary mission is the pursuit of basic research in chemical biology and medicinal chemistry, organic and materials chemistry, chemistry of natural substances, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. An integral part of the IOCB Prague’s mission is the implementation of the results of basic research in practice. Emphasis on interdisciplinary research gives rise to a wide range of applications in medicine, pharmacy, and other fields.

Source: https://www.uochb.cz/en/open-positions/297/postdoctoral-position-in-synthesis-and-chemical-biology-of-modified-rna