Přehled

Laboratory of Mitochondrial Physiology on the Institute of Physiology in Prague, Czech Republic, is seeking a scientist for a position:

Postdoctoral position in Molecular mechanisms of insulin secretion

The research project will focus on unravelling of novel molecular pathways essential for redox regulations during glucose-stimulated insulin secretion (GSIS) and etiology of type 2 diabetes (T2D). The aim is to determine mitochondrial and cytosolic targets essential in redox regulations during GSIS and a possible development of glucotoxicity- and lipotoxicity- related oxidative stress initiating T2D. Models will include insulinoma INS1E cells, isolated beta cells and Langerhans islets and transgenic mice (see Diabetes doi: 10.2337/db19-1130 and Antioxidants & Redox Signaling doi: 10.1089/ars.2019.7800). Besides standard molecular methods RNaseq, proteome-wide analyses, metabolomic analyses, pancreatic islet/animal genetic modifications will be applied.

The applicant will join an enthusiastic young team in the Institute of Physiology, ASCR. We have a strong background in mitochondrial bioenergetics and mitochondrial dynamics; in etiology of diabetes, in vitro studies of beta-cells, and 3D super-resolution microscopy.  Our laboratory has an access to the EU supported BIOCEV institute to advanced core facilities of BIOCEV. Mice breading, constructions of new knock-outs or knock-ins will be performed in cooperation with The Czech Centre for Phenogenomics (CCP) of the BIOCEV.

We seek for a highly motivated applicant with background in cell biology, biochemistry or omics technologies and bioinformatics. Background in diabetes and mitochondrial research is not necessary but beneficial.  We require a good publication record, independent thinking, and ability to work single-handedly but within the team, fluent English. Experience with cell cultures, CRISPR/Cas technology, bioenergetics, advanced microscopy techniques, animal experiments and transgenic models is an advantage. Applicants should have the PhD degree.

Requirements:

We are looking for:

  • Highly motivated, independent, creative candidates with PhD degree in cell biology, biochemistry or omics technologies and bioinformatics or related disciplines,
  • Background in diabetes is an advantage
  • Experience with cell cultures, CRISPR/Cas technology, bioenergetics, advanced microscopy techniques, animal experiments and transgenic models is an advantage
  • good publication record
  • Fluent English

We offer:

  • Working in international environment
  • Competitive salary 40.000 CZK (approx. 1 500 EUR) with a possible surplus according to involvement in other grant projects
  • Three years contract with possible extension
  • Social benefits (health insurance, contribution to pension, diets, language courses)
  • 5 weeks of holiday + 3 sick days

Further information:

The position is available from 1 January 2021. After the approval, the contract will be signed at first for three years. The contract will obey the applicable law of the Czech Republic.

Application:

Interested candidates can send their application intent containing structured curriculum vitae, motivation letter and two letters of recommendation of two independent referees.to email: marcela.tomaskova@fgu.cas.cz

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