Postdoc Position : Molecular Parasitology
Recently established research team studying signal pathways during the invasion of the Babesia parasite to the host cell offers a postdoc position.
Research description: Functional Analysis of Babesia Calcium-Dependent Protein Kinases
Babesia is a tick-transmitted parasite infecting a variety of animals including humans. Central to Babesia pathogenesis is parasitism inside host erythrocytes – an ability shared with its apicomplexan relative Plasmodium, the causative agent of malaria. Invasion to host cells and subsequent intracellular multiplication of these parasites are orchestrated by a wide repertoire of molecules including the calcium-dependent protein kinases (CDPKs). Our research is targeted to the unbiased screen of yet unrevealed Babesia divergens CDPKs and their association with fundamental biological processes using a newly established platform of transgenic techniques. Comprehensive biochemical and functional characterization of intraerythrocytic BdCDPK isoenzymes will be accompanied by their targeted inhibition using a library of Bumped Kinase Inhibitors (BKIs) to evaluate BdCDPKs as potential drug targets.
Ø interest in an academic career
Ø PhD degree in biology or chemistry
Ø analytical skills, independence and motivation
Ø excellent communication skills and sense of responsibility
Ø previsous laboratory experience and knowledge of basic methods of parasitology and molecular biology
Ø active knowledge of English
Ø knowledge of the principles of genome editing and microscopic techniques is an advantage
What do we offer :
Ø attractive research combining parasitology and molecular biology
Ø full time position for 18 months
Ø possibility of further education according to the individual motivation
Ø regular participation in foreign conferences
Ø possibility of internships abroad in cooperating laboratories
Ø 5 weeks of holidays, discounted mobile and banking services, MS Office for personal use, language courses
Start date: August/September 2023 or upon agreement
Please submit your structured CV and cover letter via e-mail to firstname.lastname@example.org by June 30th 2023. For more information, please visit: www.prf.jcu.cz .