Project: Pancreatic beta-cell and pollutants: the effect of pollutants on viability and function of pancreatic beta-cells
Mentor (Advisor): Mgr. Nela Pavlíková, PhD.
Department: Department of biochemistry, cell and molecular biology
Contact information: Email: nela.pavlikova@lf3.cuni.cz

Project Narrative: Environmental pollution represents a significant threat to human health. Epidemiological studies suggest that, among others, pollution plays a role in the worldwide epidemic of diabetes mellitus. However, data is scarce, and pollutants‘ effects on pancreatic beta-cells remain largely unexplored.

The project focuses on exploring the effects of late (e.g., DDT, DDE, HCH) and present (TDCIPP, TPhP) pollutants on the viability and function of pancreatic beta-cells. Besides the production and synthesis of insulin, it will also explore the changes in the expression of proteins essential for beta-cell survival and functionality. The project will use human, mouse, and rat beta-cell lines. Methods employed include western blot, ELISA, immunofluorescence, RT-PCR, and others.

Requirements for student applicants:

We are looking for a motivated and creative Ph.D. student interested in biomedical research and environmental toxicology. We expect enthusiasm and an active approach to solving the topic. The workplace is able to provide an increase in regular stipends. We offer work on a scientifically attractive topic under the guidance of experienced laboratory staff, support in career development, the opportunity to present results at foreign conferences, and implement foreign internships.