Two Ph.D. student positions will be available, to carry on the characterization of the meiotic roles exerted by C. elegans BRC-1 in promoting DNA repair, with particular emphasis on unravelling how posttranslational modifications regulate the activity of this protein. Moreover, we identified a completely uncharacterized BRC-1 paralog which might shed new light on the mode of function of BRC-1.

Further, functional analysis of the PARG-1-BRC-1 interaction will also be performed, possibly in a shared effort between the two Ph.D. students.

In case you are interested, please, write to: Dr.NicolaSilva (silva@med.muni.cz)