Přehled

The aim of the thesis will be the development of an efficient enzymatic synthesis of oligonucleotides on solid support. Diverse solid supports and linkers will be tested for attachment of templates and will be used for primer extension with either denaturaion or cleavage of the resulting oligonuclotides by endonucleases. Methods will be then applied for synthesis of oligonucleotides with therapeutic potential.

University:

Faculty of Science, Charles University

Group:

Michal Hocek Group, Bioorganic and Medicinal Chemistry of Nucleic Acids

Tutor:

Prof. Ing. Michal Hocek, Ph.D. DSc.

Field of study:

Organic chemistry