Přehled

The aim of the thesis will be the enzymatic synthesis of DNA bearing diverse sugars or glycans. The project will start with synthesis of diverze sugar- or glycan-linked dNTPs and their enzymatic incorporation into DNA. It will be followed by development of site-specific methods and syntheses of DNA probes bearing glycans at specific positions for targeting of relevant lectins. Collaboration with Prof. S. Messaoudi in Paris and Prof. Carmen Galan in Bristol.

University:

Faculty of Science, Charles University

Group:

Michal Hocek Group, Bioorganic and Medicinal Chemistry of Nucleic Acids

Tutor:

Prof. Ing. Michal Hocek, Ph.D. DSc.

Field of study:

Organic chemistry