Přehled

Group:

Petr Beier Group

Tutor:

Ing. Petr Beier, Ph.D.

Field of study:

Organic chemistry

Abstract:

In this project, the family of organic fluorinated azides developed by us recently1-3 will be extended by new reagents featuring fluorinated organic azides with fluorosulfonyl groups in one molecule. These new one- or two-carbon reagents will be used for efficient consecutive azide-alkyne cycloaddition and sulfur fluoride exchange (SuFEx) processes to link alkynes with nucleophiles in a chemoselective and modular way under biocompatible conditions. Applications of these reagents in synthesis, and in bioconjugation will be developed.

References:

1. Z. E. Blastik, et al. Angew. Chem., Int. Ed. 2017, 56, 346.
2. O. Bakhanovich, et al. Chem. Eur. J. 2020, 26, 77.
3. A. Markos, V. Matoušek, P. Beier Aldrichimica Acta 2022, 55, 37.

University:

Faculty of Science, Charles University

How to apply:

At the Institute of Organic Chemistry and Biochemistry of the CAS / IOCB Prague, we are looking for talented, independent, and highly motivated PhD students with an MSc. degree or equivalent in life sciences or related fields. We are offering more than 20 new exciting projects in organic and medicinal chemistry, biochemistry, molecular biology, analytical, and physical chemistry.

  • Online registration deadline: 3 March 2024
  • Interview Day: 21 March 2024

Learn more and apply at www.uochb.cz/en/call-for-phd-applications.