Overview

The topic of the dissertation will be the design and enzymatic synthesis of hypermodified xeno-nucleic acids with a combination of modifications at the base, sugar moiety and phosphate linkages. After optimization of the methodology, hypermodified XNA oligonucleotides will be prepared and tested as potential therapeutics.

University:

Faculty of Chemical Technology, UCT Prague; Faculty of Science, Charles University

Group:

Michal Hocek Group, Bioorganic and Medicinal Chemistry of Nucleic Acids

Tutor:

E – Biovědy|EB – Genetika a molekulární biologie

Field of study:

Organic chemistry