The group of Dr. Pavla Perlíková (https://uoch.vscht.cz/research-groups/perlikova-en) at the Department of Organic Chemistry of the University of Chemistry and Technology (UCT) in Prague is looking for two PhD students in organic/medicinal chemistry. The candidates will focus on the development of Arp2/3 inhibitors with antimetastatic activity.

Migrastatics represent a new concept of drugs with a great potential to improve the outcome of the current cancer treatment strategies by inhibiting metastatic behavior of cancer cells. Our goal is to use rational design to develop new inhibitors of actin polymerization by targeting the Arp2/3 complex (actin-polymerization nucleator). The project includes a synthesis of hits from virtual screening and its optimization and structure-activity relationship studies. The positions are funded by the Czech Science Foundation.

We offer:

  • Study at the largest higher education institution devoted to education and research in the field of chemistry in Central Europe
  • Work in a small team and friendly environment
  • 36-month contract (0.75 FTE + scholarship)
    Low cost of living in tolerant, progressive and secure country with rich cultural and natural heritage
    Study in the heart of Europe with convenient transport connections to the whole world

We are looking for:

  • Highly motivated candidates with background in synthetic organic chemistry
  • MSc. degree in organic/medicinal chemistry (or a soon-to-be graduate)
  • Pro-active, flexible and responsible students
  • Excellent command of English (oral and written)


  • Interviews to be conducted in March 2023
  • Expected start: September 2023

How to apply

Please send a motivation letter covering the reason for application, skills and abilities, which make the applicant a good candidate, professional interests and expectations (maximum one page), your CV including a list of publications, and a letter of recommendation by the MSc. advisor via email to pavla.perlikova@vscht.cz. Applications are accepted until February 28th 2023. Short-listed candidates will be invited to an online interview.